GeneSilencing相关论文
目的:观察整合素连接激酶-小干扰RNA-特异性腺相关病毒(ILK-siRNA-AAV)对大鼠青光眼滤过术后滤过通道瘢痕形成的抑制作用。方法:选......
An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safet
Gene therapy using small interfering RNA (siRNA) is emerging as a novel therapeutic approach to treat various diseases.H......
目的:探讨n K-ras基因对PMn 2.5染毒人支气管上皮（HBE）细胞部分癌基因和抑癌基因表达的影响。n 方法:于2019年9月，根据......
The concept of controlling the release of therapeutically active agents using polymers is an established approach that h......
Antibodies have been applied for the development of targeted gene delivery systems.Single chain antibodies targeting Her......
Dendrimers have become prominent synthetic macromolecules for drug delivery thanks to their unique properties of high dr......
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Identification of hypersensitive response (HR) regulators is essential to dissect the molecular mechanisms underlying pl......
Formation of dendrimer-modified MoS2 nanoflowers for combinational gene silencing and photothermal t
Exploitation of novel hybrid nanomaterials for combinational tumor therapy still remains to be challenging.In this work,......
White adipose tissue (WAT) as an anti-obesity drug target has brought much-needed attention due to the recent discoverie......
Phenotypic, Molecular and Phytohormonal Evidences of Plum Pox Virus Silencing in Susceptible Apricot
Plum pox virus(PPV,sharka disease)is the most important limiting factor for apricot production in affected areas.The cul......
Transcriptional Changes in Epigenetic Modifiers Associated with Gene Silencing in the Intestine of t
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Self-assembly nanoparticles based on c(RGDfk) peptide for the delivery of siRNA targeting VEGFR2 gen
The clinical application of small interference RNA (siRNA) has been restricted by poor intracellular uptake, low serum s......
Transfection efficacy and silencing effects of Lipofectamin RNAiMAX-mediated siRNA transfection into
Cationic liposome-mediated siRNA transfection is a common,easy,and economic gene silencing method.But this technique exh......
Correlations of physicochemical stability, cellular association and gene silencing efficiency of tri
N,N,N- trimethyl chitosan (TMC) with a quaternization degree of 40％ was used as a vectorfor siRNA delivery. Nano-sized co......
Ligand-Conjugated siRNA Delivery Systems Localizes in Hepatocytes and Elicits Robust RNAi-Mediated G
Synthetic small interfering RNAs(siRNAs)can inhibit expression of disease-causing genes through post-transcriptional gen......
Although considerable clinical attempts on various types of cancers have achieved,photodynamic therapy(PDT)still suffers......
Conditional regulation of siRNA functions will be highly useful,particularly through regulation of specific gene express......
p38 as a member of MAPK family,has been conversed from yeast to mammals.It has been implicated in numerous biological pr......
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Objective:By the technology of RNA interfering, we want to construct three different vectors pGreenPuroTM shRNA Cloning ......
The Study on the Induction Function of SiRNA Mediated Survivin Gene Silence on Nasopharyngeal Carcin
To explore the function of Survivin gene expression in patients with nasopharyngeal carcinoma (NPC) and siRNA on con......
RNAi(RNA interference)was discovered in recent years,which is a gene silencing phenomenon caused by double-stranded ......
目的探讨高压氧协同靶向水通道蛋白-4(aquaporin 4，AQP-4)的RNA干扰(RNA interference，RNAi)技术对改善脑创伤(trauma brain injury，T......
Heterochromatin is characteristically more compact than euchromatin in the eukaryotic genome. The establishment of heter......
Most eukaryotes employ a variety of mechanisms to defend the integrity of their genome by recognizing and silencing para......
Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precur
MiR-219 and miR-338 (miR-219/miR-338) are oligodendrocyte-specific microRNAs. The overexpression of these miRs in oligod......
基因沉默是广泛存在于生物界的古老现象,是生物体抵御病毒或其它外来核酸入侵以及保持自身遗传稳定的保护性机制,广泛存在于真核生......
目的探讨沉默叉头盒O类转录因子-3a(FoxO3a)活性是否影响人卵巢癌SKOV3细胞系肿瘤球形成能力。方法干细胞条件培养基悬浮培养法得......
Downregulation of retinoic acid receptor-β2expression is linked to aberrant methylation in esophagea
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目的 探讨吉西他滨对Beclinl基因沉默的人胰腺癌MiaPaCa-2细胞周期及凋亡的影响.方法 构建靶向Beclinl的siRNA,插入表达质粒,转染M......
目的观察截短型p63(ΔNp63)基因沉默对胰腺癌PANC1细胞增殖的影响。方法采用实时PCR检测23例胰腺癌及其配对癌旁正常胰腺组织ΔNp6......
The effects of targeted silencing of heparanase gene by small interfering RNA (siRNA) on invasiveness and metastasis of ......
Processing of mature transfer RNAs(tRNAs)produces complex populations of tRNA-derived fragments(tRFs).Emerging evidence ......
目的近年来,双链RNA介导的基因沉默(RNA干扰)已在许多动植物中发现,并成为研究基因功能的强有力的工具.为确定蚊虫细胞中是否有RNA......
表观遗传调控在基因表达、DNA复制、修复和重组等重要过程中起着关键作用，表观遗传调控异常会引发多种疾病尤其是癌症。SNF5是SWI-S......
目的：观察抑制Dickkopf-1和Sclerostin表达对人成骨肉瘤细胞MG63骨代谢调节相关蛋白表达水平的影响。方法：培养MG63细胞,构建沉默Dic......
